{"id":431,"date":"2022-10-24T21:57:07","date_gmt":"2022-10-24T21:57:07","guid":{"rendered":"https:\/\/centrodemiastenia.com\/medicos\/?page_id=431"},"modified":"2022-11-16T19:42:20","modified_gmt":"2022-11-16T19:42:20","slug":"tratamiento","status":"publish","type":"page","link":"https:\/\/centrodemiastenia.com\/medicos\/tratamiento\/","title":{"rendered":"Tratamiento"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"431\" class=\"elementor elementor-431\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6e2acda8 elementor-section-height-min-height elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"6e2acda8\" data-element_type=\"section\" id=\"miastenia\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-13ac841c\" data-id=\"13ac841c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3980d98c elementor-widget elementor-widget-image\" data-id=\"3980d98c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.1 - 13-11-2022 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1770\" height=\"314\" src=\"https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666.png 1770w, https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666-300x53.png 300w, https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666-1024x182.png 1024w, https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666-768x136.png 768w, https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666-1536x272.png 1536w\" sizes=\"(max-width: 1770px) 100vw, 1770px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-27b7cc72 elementor-section-height-min-height elementor-section-items-bottom elementor-hidden-mobile elementor-section-boxed elementor-section-height-default\" data-id=\"27b7cc72\" data-element_type=\"section\" id=\"miastenia\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9d8a533\" data-id=\"9d8a533\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1f3affe5 elementor-widget elementor-widget-image\" data-id=\"1f3affe5\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1770\" height=\"314\" src=\"https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666.png\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666.png 1770w, https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666-300x53.png 300w, https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666-1024x182.png 1024w, https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666-768x136.png 768w, https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Component-1-\u2013-1-e1666120104666-1536x272.png 1536w\" sizes=\"(max-width: 1770px) 100vw, 1770px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-348588c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"348588c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7da64c4\" data-id=\"7da64c4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cd4cf50 elementor-widget elementor-widget-heading\" data-id=\"cd4cf50\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.1 - 13-11-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">TRATAMIENTO<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-42244ab elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"42244ab\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-c29b20b\" data-id=\"c29b20b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4017ba7b elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"4017ba7b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.1 - 13-11-2022 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#818a91;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#818a91;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\tEn la actualidad, el objetivo del tratamiento es que el paciente alcance la remisi\u00f3n completa o el estado de m\u00ednima manifestaci\u00f3n, es decir, que se encuentre asintom\u00e1tico y sin limitaciones funcionales causadas por la enfermedad. Estos beneficios deben acompa\u00f1arse de los m\u00ednimos efectos adversos que sea posible.<sup>11<\/sup>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dfabc22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dfabc22\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b4c5902\" data-id=\"b4c5902\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2ea22f1 elementor-widget elementor-widget-heading\" data-id=\"2ea22f1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Las estrategias terap\u00e9uticas son cuatro:<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7cfda2b elementor-widget elementor-widget-spacer\" data-id=\"7cfda2b\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.8.1 - 13-11-2022 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));-ms-flex-item-align:stretch;align-self:stretch;-ms-flex-negative:0;flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-79f1abe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"79f1abe\" data-element_type=\"section\" id=\"cuadro-icon\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-5b01ec98\" data-id=\"5b01ec98\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1da3e368 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1da3e368\" data-element_type=\"section\" id=\"card-tratamiento\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-3554debe\" data-id=\"3554debe\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1325bba8 elementor-widget elementor-widget-image\" data-id=\"1325bba8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"101\" height=\"101\" src=\"https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Icono_Medicina-copy.svg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d50325 elementor-widget elementor-widget-spacer\" data-id=\"4d50325\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-279461c elementor-widget elementor-widget-heading\" data-id=\"279461c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">TRATAMIENTO <br>SINTOM\u00c1TICO<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-74b18579 elementor-widget elementor-widget-spacer\" data-id=\"74b18579\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6cf5bc32 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"6cf5bc32\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#TRATAMIENTO\" class=\"elementor-button-link elementor-button elementor-size-xs\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Ver m\u00e1s<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-445310e\" data-id=\"445310e\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2ff4f62 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ff4f62\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-5592ca7\" data-id=\"5592ca7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-02c740f elementor-widget elementor-widget-image\" data-id=\"02c740f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"106\" height=\"106\" src=\"https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Vector-Smart-Object.svg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57fc180 elementor-widget elementor-widget-spacer\" data-id=\"57fc180\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b54d17c elementor-widget elementor-widget-heading\" data-id=\"b54d17c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">TRATAMIENTO <br>INMUNOSUPRESOR<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01b26dc elementor-widget elementor-widget-spacer\" data-id=\"01b26dc\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-170ac81 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"170ac81\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#TRATAMIENTO-IN\" class=\"elementor-button-link elementor-button elementor-size-xs\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Ver m\u00e1s<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-94e7269\" data-id=\"94e7269\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9180f19 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9180f19\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-6d21b6d\" data-id=\"6d21b6d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-671aa33 elementor-widget elementor-widget-image\" data-id=\"671aa33\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"79\" height=\"94\" src=\"https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Icono_Timectomia.svg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-85c5451 elementor-widget elementor-widget-spacer\" data-id=\"85c5451\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24c3e98 elementor-widget elementor-widget-heading\" data-id=\"24c3e98\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">TIMECTOM\u00cdA<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f742c5 elementor-widget elementor-widget-spacer\" data-id=\"8f742c5\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-34a6f13 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"34a6f13\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#TIMECTOMiA\" class=\"elementor-button-link elementor-button elementor-size-xs\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Ver m\u00e1s<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-6a78a94\" data-id=\"6a78a94\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a7bbcb5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a7bbcb5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-7bd15d6\" data-id=\"7bd15d6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1de9878 elementor-widget elementor-widget-image\" data-id=\"1de9878\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"101\" height=\"109\" src=\"https:\/\/centrodemiastenia.com\/medicos\/wp-content\/uploads\/sites\/3\/2022\/10\/Icono_Intravenoso.svg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-768fc22 elementor-widget elementor-widget-spacer\" data-id=\"768fc22\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7ad1f3 elementor-widget elementor-widget-heading\" data-id=\"f7ad1f3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">INMUNOGLOBULINA <br>INTRAVENOSA \/ PLASMAF\u00c9RESIS<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-532457a elementor-widget elementor-widget-spacer\" data-id=\"532457a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-915bc66 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"915bc66\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#INMUNOGLOBULINA\" class=\"elementor-button-link elementor-button elementor-size-xs\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-angle-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Ver m\u00e1s<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4f37eb16 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4f37eb16\" data-element_type=\"section\" id=\"TRATAMIENTO\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1a9f778f\" data-id=\"1a9f778f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-048b861 elementor-widget elementor-widget-heading\" data-id=\"048b861\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">TRATAMIENTO SINTOM\u00c1TICO<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5bffe21 elementor-widget elementor-widget-spacer\" data-id=\"5bffe21\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8e6cf5d elementor-widget elementor-widget-text-editor\" data-id=\"8e6cf5d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022 Los inhibidores de la enzima acetilcolinesterasa (ICE), conocidos como anticolinester\u00e1sicos, reducen la hidr\u00f3lisis de la acetilcolina, aumentando as\u00ed sus niveles disponibles en la uni\u00f3n neuromuscular.<sup>1,4<\/sup><br \/>\u2022 La inhibici\u00f3n es reversible y el efecto dura 3 a 4 horas.<sup>1,4<\/sup><br \/>\u2022 Son seguros, efectivos y constituyen la primera l\u00ednea de tratamiento para todos los pacientes.<sup>1<\/sup><br \/>\u2022 Los CEI incluyen la piridostigmina y la neostigmina.1 Pueden indicarse a ni\u00f1os y aultos.<sup>1<\/sup><br \/>\u2022 Ambos CEI pueden administrarse por v\u00eda oral o parenteral (cuando est\u00e1 disponible), subcut\u00e1nea, intravenosa o intramuscular.<sup>1<\/sup><br \/>\u2022 Los efectos secundarios muscar\u00ednicos son frecuentes e incluyen malestar gastrointestinal, diarrea, salivaci\u00f3n, lagrimeo y diaforesis.<sup>1,4<\/sup> Los efectos adversos nicot\u00ednicos son: calambres, fasciculaciones, debilidad muscular. En la crisis colin\u00e9rgica hay severa debilidad acompa\u00f1ada de s\u00edntomas y signos muscar\u00ednicos, los cuales no est\u00e1n presentes en la crisis miast\u00e9nica.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f94244 elementor-align-right elementor-widget elementor-widget-button\" data-id=\"1f94244\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#\" class=\"elementor-button-link elementor-button elementor-size-xs\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" width=\"11\" height=\"8\" viewBox=\"0 0 11 8\"><defs><clipPath id=\"clip-path\"><rect id=\"Rectangle_8\" data-name=\"Rectangle 8\" width=\"11\" height=\"8\" transform=\"translate(0 0)\" fill=\"none\"><\/rect><\/clipPath><\/defs><g id=\"Arrow_4_copy_5\" data-name=\"Arrow 4 copy 5\" transform=\"translate(-1490 -1939)\"><g id=\"Arrow_4_copy_5-2\" data-name=\"Arrow 4 copy 5\" transform=\"translate(1490 1939)\"><g id=\"Group_17\" data-name=\"Group 17\"><g id=\"Group_16\" data-name=\"Group 16\" clip-path=\"url(#clip-path)\"><path id=\"Path_16\" data-name=\"Path 16\" d=\"M10.782,6.311,6.249.328A.788.788,0,0,0,5.632,0a.776.776,0,0,0-.6.309L.234,6.29A1.163,1.163,0,0,0,.256,7.718a.741.741,0,0,0,1.183-.026L5.614,2.483,9.545,7.672A.782.782,0,0,0,10.163,8a.761.761,0,0,0,.565-.264,1.162,1.162,0,0,0,.053-1.425\" fill=\"#7da431\"><\/path><\/g><\/g><\/g><path id=\"Color_Overlay\" data-name=\"Color Overlay\" d=\"M1499.546,1946.671l-3.931-5.188-4.175,5.208a.741.741,0,0,1-1.184.026,1.161,1.161,0,0,1-.021-1.427l4.794-5.981a.743.743,0,0,1,1.22.02l4.533,5.982a1.112,1.112,0,0,1,.218.669V1946a1.107,1.107,0,0,1-.271.737.758.758,0,0,1-.564.265A.783.783,0,0,1,1499.546,1946.671Z\" fill=\"#fff\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\"> <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b1dfdfc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b1dfdfc\" data-element_type=\"section\" id=\"TRATAMIENTO-IN\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-351894b\" data-id=\"351894b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12e8e32 elementor-widget elementor-widget-heading\" data-id=\"12e8e32\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">TRATAMIENTO INMUNOSUPRESOR<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d97ac15 elementor-widget elementor-widget-heading\" data-id=\"d97ac15\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores de los mecanismos efectores de la v\u00eda del complemento<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-44fe14c elementor-widget elementor-widget-text-editor\" data-id=\"44fe14c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022 Los inmunosupresores est\u00e1n indicados en los pacientes que contin\u00faan sintom\u00e1ticos a pesar del uso adecuado de anticolinestr\u00e1sicos.<sup>4<\/sup><br \/>\u2022 Deber\u00edan iniciarse temprano en las formas de MG generalizada debido a que la medicaci\u00f3n sintom\u00e1tica en monoterapia suele ser insuficiente para controlar la enfermedad.<sup>11<\/sup><br \/>\u2022 La elecci\u00f3n de la terapia inmunosupresora plantea desaf\u00edos importantes debido a la heterogeneidad de fenotipos, inmunopatolog\u00eda subyacente y respuesta a diferentes f\u00e1rmacos.<sup>11<\/sup><br \/>\u2022 En la medida que se disponga de nuevas opciones terap\u00e9uticas, la elecci\u00f3n deber\u00e1 individualizarse y ser\u00e1 importante conocer el mecanismo de acci\u00f3n de cada clase de f\u00e1rmaco, en especial, de los agentes biol\u00f3gicos dirigidos a blancos espec\u00edficos del sistema inmune.<sup>11<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d96b876 elementor-widget elementor-widget-heading\" data-id=\"d96b876\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Terapias inmunospresoras<sup>1,4,11-14<\/sup>\n<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2b2078f elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2b2078f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6a3bf60\" data-id=\"6a3bf60\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-213300c elementor-widget elementor-widget-heading\" data-id=\"213300c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">CLASE DE F\u00c1RMACOS <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a94621c\" data-id=\"a94621c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-891a380 elementor-widget elementor-widget-heading\" data-id=\"891a380\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">F\u00c1RMACOS<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-cfbe13d elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cfbe13d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3a9062f\" data-id=\"3a9062f\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eca4983 elementor-widget elementor-widget-heading\" data-id=\"eca4983\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">CORTICOESTEROIDES<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-074f01a\" data-id=\"074f01a\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-992056e elementor-widget elementor-widget-heading\" data-id=\"992056e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Prednisona<br>\n\u2022 Meprednisona<br>\n\u2022 Metilprednisolona <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6bb4ede elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6bb4ede\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4849077\" data-id=\"4849077\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-faa6f7b elementor-widget elementor-widget-heading\" data-id=\"faa6f7b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">ANTIMETABOLITOS<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3540dd0\" data-id=\"3540dd0\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-edadbe4 elementor-widget elementor-widget-heading\" data-id=\"edadbe4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Azatioprina<br>\n\u2022 Micofenolato mofetil<br>\n\u2022 Metotrexato<br>\n\u2022 Ciclofosfamida<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b8193ec elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b8193ec\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c4c0132\" data-id=\"c4c0132\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0cb6b6e elementor-widget elementor-widget-heading\" data-id=\"0cb6b6e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">INHIBIDORES DE CALCINEURINA<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-12fab5b\" data-id=\"12fab5b\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-19c6960 elementor-widget elementor-widget-heading\" data-id=\"19c6960\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Ciclosporina<br>\n\u2022 Tacrolimus<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-849c744 elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"849c744\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5e93245\" data-id=\"5e93245\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-09c7d73 elementor-widget elementor-widget-heading\" data-id=\"09c7d73\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">F\u00c1RMACOS BIOL\u00d3GICOS\n<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a93f76f elementor-widget elementor-widget-heading\" data-id=\"a93f76f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores de los mecanismos efectores de la v\u00eda del complemento<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-cc57cb1\" data-id=\"cc57cb1\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-76b1e00 elementor-widget elementor-widget-heading\" data-id=\"76b1e00\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Eculizumab<br>\n\u2022 Ravulizumab*<br>\n\u2022 Zilucoplan*<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-fe6d974 elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fe6d974\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6fbeee5\" data-id=\"6fbeee5\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-41cad17 elementor-widget elementor-widget-heading\" data-id=\"41cad17\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores del receptor neonatal Fc (FcRn), que disminuyen los niveles de IgG circulante<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9e414a9\" data-id=\"9e414a9\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a673aef elementor-widget elementor-widget-heading\" data-id=\"a673aef\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Efgartigimod*<br>\n\u2022 Rozanolixizumab*<br>\n\u2022 Nipocalimab* <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3b6c062 elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b6c062\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6a8b65b\" data-id=\"6a8b65b\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5f933e1 elementor-widget elementor-widget-heading\" data-id=\"5f933e1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Depletores de linfocitos CD20, que reducen la producci\u00f3n de Ac<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-c441ebe\" data-id=\"c441ebe\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2952b36 elementor-widget elementor-widget-heading\" data-id=\"2952b36\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Rituximab <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-5e8e97d elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5e8e97d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3e5323f\" data-id=\"3e5323f\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-30e058a elementor-widget elementor-widget-heading\" data-id=\"30e058a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Depletores de linfocitos CD20, que reducen la producci\u00f3n de Ac<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b3be057\" data-id=\"b3be057\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-072a2f0 elementor-widget elementor-widget-heading\" data-id=\"072a2f0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Rituximab <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-50cf1c7 elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"50cf1c7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e0371db\" data-id=\"e0371db\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4fefc1f elementor-widget elementor-widget-heading\" data-id=\"4fefc1f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores del proteasoma, que genera apoptosis de c\u00e9lulas plasm\u00e1ticas<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5c642be\" data-id=\"5c642be\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2ed62c7 elementor-widget elementor-widget-heading\" data-id=\"2ed62c7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Bortezomib** \n\n\n<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2633c93 elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2633c93\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-3f88442\" data-id=\"3f88442\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0cf5c42 elementor-widget elementor-widget-heading\" data-id=\"0cf5c42\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores del factor de activaci\u00f3n de linfocitos B (BAFF)<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-8287396\" data-id=\"8287396\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b939ec6 elementor-widget elementor-widget-heading\" data-id=\"b939ec6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Bortezomib** \n\n\n<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2c93124 elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2c93124\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5fc0aad\" data-id=\"5fc0aad\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c28fbbf elementor-widget elementor-widget-heading\" data-id=\"c28fbbf\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores de CD40<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-cf2c34f\" data-id=\"cf2c34f\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-818df16 elementor-widget elementor-widget-heading\" data-id=\"818df16\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Iscalimab** <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-37bf334 elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"37bf334\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-2c07c7d\" data-id=\"2c07c7d\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6a34a8e elementor-widget elementor-widget-heading\" data-id=\"6a34a8e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">CLASE DE F\u00c1RMACOS <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-de1a8f4 elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"de1a8f4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-3189136\" data-id=\"3189136\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-44865f5 elementor-widget elementor-widget-heading\" data-id=\"44865f5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">CORTICOESTEROIDES<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-076c7eb elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"076c7eb\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-8312578\" data-id=\"8312578\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bc59a67 elementor-widget elementor-widget-heading\" data-id=\"bc59a67\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">ANTIMETABOLITOS<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-48ab97d elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"48ab97d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-391b69a\" data-id=\"391b69a\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e4d9512 elementor-widget elementor-widget-heading\" data-id=\"e4d9512\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">INHIBIDORES DE CALCINEURINA<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7dc304f elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7dc304f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-d47e980\" data-id=\"d47e980\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2e28f30 elementor-widget elementor-widget-heading\" data-id=\"2e28f30\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">F\u00c1RMACOS BIOL\u00d3GICOS\n<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-832680f elementor-widget elementor-widget-heading\" data-id=\"832680f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores de los mecanismos efectores de la v\u00eda del complemento<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9c85316 elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9c85316\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-58d7f0e\" data-id=\"58d7f0e\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e0db6ca elementor-widget elementor-widget-heading\" data-id=\"e0db6ca\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores del receptor neonatal Fc (FcRn), que disminuyen los niveles de IgG circulante<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-90aa7c2 elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"90aa7c2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-2b83ef9\" data-id=\"2b83ef9\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-71dfb59 elementor-widget elementor-widget-heading\" data-id=\"71dfb59\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Depletores de linfocitos CD20, que reducen la producci\u00f3n de Ac<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-221551e elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"221551e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-8ce5c9a\" data-id=\"8ce5c9a\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-482f69c elementor-widget elementor-widget-heading\" data-id=\"482f69c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Depletores de linfocitos CD20, que reducen la producci\u00f3n de Ac<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-180c15f elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"180c15f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-ca28aa3\" data-id=\"ca28aa3\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25a137e elementor-widget elementor-widget-heading\" data-id=\"25a137e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores del proteasoma, que genera apoptosis de c\u00e9lulas plasm\u00e1ticas<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-6535cc1\" data-id=\"6535cc1\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dc2178c elementor-widget elementor-widget-heading\" data-id=\"dc2178c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores del factor de activaci\u00f3n de linfocitos B (BAFF)<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-e35f932\" data-id=\"e35f932\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-357003e elementor-widget elementor-widget-heading\" data-id=\"357003e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Inhibidores de CD40<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2386ce6 elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2386ce6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-62b9bc4\" data-id=\"62b9bc4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d96a7ba elementor-widget elementor-widget-heading\" data-id=\"d96a7ba\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">F\u00c1RMACOS<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-5088cc4\" data-id=\"5088cc4\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b0ca4d4 elementor-widget elementor-widget-heading\" data-id=\"b0ca4d4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Prednisona<br>\n\u2022 Meprednisona<br>\n\u2022 Metilprednisolona <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-28ed9e2\" data-id=\"28ed9e2\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-15a7ff0 elementor-widget elementor-widget-heading\" data-id=\"15a7ff0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Azatioprina<br>\n\u2022 Micofenolato mofetil<br>\n\u2022 Metotrexato<br>\n\u2022 Ciclofosfamida<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-bf0a06c\" data-id=\"bf0a06c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-88b4f7a elementor-widget elementor-widget-heading\" data-id=\"88b4f7a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Ciclosporina<br>\n\u2022 Tacrolimus<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-aaf04e0\" data-id=\"aaf04e0\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8c8c214 elementor-widget elementor-widget-heading\" data-id=\"8c8c214\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Eculizumab<br>\n\u2022 Ravulizumab*<br>\n\u2022 Zilucoplan*<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-a94a6a2\" data-id=\"a94a6a2\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a34211d elementor-widget elementor-widget-heading\" data-id=\"a34211d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Efgartigimod*<br>\n\u2022 Rozanolixizumab*<br>\n\u2022 Nipocalimab* <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-bf21efc\" data-id=\"bf21efc\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ea49a04 elementor-widget elementor-widget-heading\" data-id=\"ea49a04\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Rituximab <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-42a4770\" data-id=\"42a4770\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-df27e3a elementor-widget elementor-widget-heading\" data-id=\"df27e3a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Rituximab <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-1ac3b3e\" data-id=\"1ac3b3e\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ea8df9a elementor-widget elementor-widget-heading\" data-id=\"ea8df9a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Bortezomib** \n\n\n<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-10 elementor-inner-column elementor-element elementor-element-e1cd066\" data-id=\"e1cd066\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ac25b4f elementor-widget elementor-widget-heading\" data-id=\"ac25b4f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u2022 Iscalimab** <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4d3e61 elementor-widget elementor-widget-spacer\" data-id=\"b4d3e61\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1e0ba22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1e0ba22\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-53a28eb\" data-id=\"53a28eb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-249ba61 elementor-widget elementor-widget-text-editor\" data-id=\"249ba61\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>*F\u00e1rmacos biol\u00f3gicos evaluados en ensayos cl\u00ednicos de fase II o III, en curso o completados a la fecha, con evidencia de potencial beneficio. **F\u00e1rmacos biol\u00f3gicos con potencial para tratar la miastenia, evaluados solo en casos aislados o estudios peque\u00f1os.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-dbe8b1f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dbe8b1f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-89888ab\" data-id=\"89888ab\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9e20ca6 elementor-widget elementor-widget-heading\" data-id=\"9e20ca6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Corticoesteroides <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e72950 elementor-widget elementor-widget-text-editor\" data-id=\"3e72950\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022 Los corticoesteroides son el primer inmunosupresor que se administra a los pacientes con miastenia moderada a grave, refractaria a los anticolinester\u00e1sicos.<sup>1<\/sup><br \/>\u2022 Tienen efectos amplios sobre el sistema inmune y son eficaces en cerca del 80% de los pacientes, en conjunto.<sup>1,11<\/sup><br \/>\u2022 La prednisona se administra por v\u00eda oral y la metilprednisolona, por v\u00eda intravenosa.<sup>1<\/sup><br \/>\u2022 Habitualmente, se inician en dosis alta y una vez alcanzada respuesta, la dosis debe reducirse lentamente.<sup>1<\/sup><br \/>\u2022 Aunque el objetivo es lograr la suspensi\u00f3n, muchos pacientes requieren continuar con dosis m\u00ednimas, generalmente en d\u00edas alternos, para mantener la respuesta cl\u00ednica.<sup>1,11<\/sup><br \/>\u2022 El principal problema de la corticoterapia cr\u00f3nica son las complicaciones: hipertensi\u00f3n arterial, osteoporosis, diabetes, cataratas, etc. Para evitarlas, es habitual la administraci\u00f3n de otros inmunosupresores que permiten reducir o \u201cahorrar\u201d dosis del corticoesteroide.<sup>1,11<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4122f84 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4122f84\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-ccbc37a\" data-id=\"ccbc37a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c293949 elementor-widget elementor-widget-heading\" data-id=\"c293949\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Antimetabolitos <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8d3f970 elementor-widget elementor-widget-text-editor\" data-id=\"8d3f970\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022 La azatioprina tiene extenso uso en MG como agente \u201cahorrador\u201d de esteroides, pero se requieren 4 a 8 meses de tratamiento para el inicio de efecto cl\u00ednico.<sup>1,11<\/sup> Con frecuencia se administra a mujeres con potencial para procrear (no ser\u00eda teratog\u00e9nica).<sup>12<\/sup> Toxicidad: hep\u00e1tica, inhibici\u00f3n de m\u00e9dula \u00f3sea con leucopenia, macrocitosis.<sup>1<\/sup><br \/>\u2022 Con micofenolato mofetil, estudios observacionales y la experiencia profesional indican que cerca del 75% de los pacientes obtienen beneficio cl\u00ednico y logran reducir la dosis de esteroides, aunque estudios m\u00e1s recientes han cuestionado su papel.<sup>1,11<\/sup><br \/>\u2022 El metotrexato se ha usado en pacientes seleccionados, con eficacia similar a la azatioprina en informes aislados.<sup>1,11<\/sup> Se sugiere solo en pacientes con MG generalizada con intolerancia o falta de respuesta a otros inmunosupresores.<sup>11,15<\/sup><br \/>\u2022 La ciclofosfamida se reserva para la MG refractaria, sin respuesta a la terapia convencional.<sup>11<\/sup> Es teratog\u00e9nica y posee alto riesgo de toxicidad.<sup>11<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6bfa1c4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6bfa1c4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-55f2328\" data-id=\"55f2328\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f909298 elementor-widget elementor-widget-heading\" data-id=\"f909298\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Inhibidores de calcineurina <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-207faf1 elementor-widget elementor-widget-text-editor\" data-id=\"207faf1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022 Reservados para los pacientes con formas graves de miastenia, refractarios a la asociaci\u00f3n de prednisona con azatioprina o micofenolato mofetil.<sup>1,11<\/sup><br \/>\u2022 Ambos, ciclosporina A y tacrolimus, brindan beneficio cl\u00ednico pero el uso es limitado por la toxicidad, especialmente renal.<sup>8<\/sup> Se requiere monitoreo de los niveles en sangre de estos f\u00e1rmacos.<sup>1<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4ad91db elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4ad91db\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-c680187\" data-id=\"c680187\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd5e36e elementor-widget elementor-widget-heading\" data-id=\"fd5e36e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Terapias biol\u00f3gicas<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0733067 elementor-widget elementor-widget-text-editor\" data-id=\"0733067\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022 La b\u00fasqueda de f\u00e1rmacos eficaces y bien tolerados para tratar la miastenia ha sido impulsada por varios motivos: el porcentaje de pacientes refractarios a todas las opciones terap\u00e9uticas disponibles, la elevada tasa de eventos adversos y toxicidad con los inmunosupresores convencionales, y el mayor conocimiento de los mecanismos inmunopatol\u00f3gicos de la enfermedad.<sup>12,13<\/sup><br \/>\u2022 Los avances tecnol\u00f3gicos han permitido desarrollar y probar diferentes mol\u00e9culas, fundamentalmente anticuerpos monoclonales, cuyos blancos terap\u00e9uticos son diversos componentes del sistema inmunitario: poblaciones de linfocitos T o B, la cascada de complemento, el fragmento Fc neonatal de la inmunoglobulina G (FcRn) y citocinas proinflamatorias (<u>Ver Tabla de Terapias inmunosupresoras<\/u>).<sup>11,12<\/sup><br \/>\u2022 En el futuro, es posible que el tratamiento de la miastenia gravis sea individualizado en base al tipo de anticuerpos y el mecanismo de acci\u00f3n de los f\u00e1rmacos.<sup>11<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-d52a4e1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d52a4e1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-37e0227\" data-id=\"37e0227\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e96b961 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"e96b961\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">A la fecha, los dos f\u00e1rmacos biol\u00f3gicos que han alcanzado uso cl\u00ednico son rituximab y eculizumab.<sup>1,11,12<\/sup><\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b5f3a7 elementor-widget elementor-widget-spacer\" data-id=\"5b5f3a7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50da091 elementor-widget elementor-widget-text-editor\" data-id=\"50da091\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022 El rituximab es un Ac monoclonal IgG1 quim\u00e9rico, dirigido contra las c\u00e9lulas CD20, que genera depleci\u00f3n de linfocitos B. Diversas series de casos confirman su eficacia para controlar los s\u00edntomas y reducir la dosis de esteroides, con comienzo de acci\u00f3n relativamente r\u00e1pido. De inter\u00e9s, se obtienen resultados favorables en la MG con Ac anti MuSK positivos. Se asocia con buena tolerancia. El uso en MG es off-label.<sup>1,11,12,15<\/sup><br \/>\u2022 El eculizumab es un Ac monoclonal humanizado recombinante IgG2\/4K, dirigido contra la prote\u00edna C5 del complemento, que bloquea la activaci\u00f3n terminal de dicha v\u00eda. Est\u00e1 aprobado por las autoridades regulatorias en EE. UU., Europa y Jap\u00f3n para tratar la MG generalizada con AChRA positivos, refractaria. Estudios cl\u00ednicos de fase II y III demostraron que eculizumab mejor\u00f3 el puntaje de todas las escalas de evaluaci\u00f3n sintom\u00e1tica y funcional de la miastenia y redujo las exacerbaciones, con beneficio sostenido en el seguimiento hasta 4 a\u00f1os. Los pacientes deben recibir inmunizaci\u00f3n previa contra Neisseria meningitidis debido al riesgo de infecci\u00f3n meningoc\u00f3cica.<sup>11,12,14<\/sup><br \/>\u2022 El ravulizumab, otro inhibidor del complemento C5, podr\u00eda ser una opci\u00f3n para la miastenia AChRA positiva refractaria, y posee la ventaja de vida media m\u00e1s prolongada que eculizumab.<sup>14<\/sup><br \/>\u2022 El efgartigimod es el inhibidor de FcRn m\u00e1s avanzado en el desarrollo cl\u00ednico, con estudios de fase III completados. El f\u00e1rmaco se asoci\u00f3 con mejor\u00eda cl\u00ednica significativa, reducci\u00f3n de hasta 70% en los niveles de IgG s\u00e9rica y perfil de seguridad adecuado.<sup>14<\/sup> Los inhibidores de FcRn pueden inducir depleci\u00f3n prolongada de IgG y podr\u00edan representar una opci\u00f3n en primera l\u00ednea para la inmunosupresi\u00f3n a largo plazo.<sup>13<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-807ea7c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"807ea7c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-d3d21ce\" data-id=\"d3d21ce\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-105d82e elementor-align-left elementor-widget elementor-widget-button\" data-id=\"105d82e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#\" class=\"elementor-button-link elementor-button elementor-size-md\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-chevron-right\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\"> M\u00e1s informaci\u00f3n en la Secci\u00f3n Bibliograf\u00eda de esta web<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b340fc2\" data-id=\"b340fc2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f3f30e7 elementor-align-right elementor-widget elementor-widget-button\" data-id=\"f3f30e7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#\" class=\"elementor-button-link elementor-button elementor-size-xs\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" width=\"11\" height=\"8\" viewBox=\"0 0 11 8\"><defs><clipPath id=\"clip-path\"><rect id=\"Rectangle_8\" data-name=\"Rectangle 8\" width=\"11\" height=\"8\" transform=\"translate(0 0)\" fill=\"none\"><\/rect><\/clipPath><\/defs><g id=\"Arrow_4_copy_5\" data-name=\"Arrow 4 copy 5\" transform=\"translate(-1490 -1939)\"><g id=\"Arrow_4_copy_5-2\" data-name=\"Arrow 4 copy 5\" transform=\"translate(1490 1939)\"><g id=\"Group_17\" data-name=\"Group 17\"><g id=\"Group_16\" data-name=\"Group 16\" clip-path=\"url(#clip-path)\"><path id=\"Path_16\" data-name=\"Path 16\" d=\"M10.782,6.311,6.249.328A.788.788,0,0,0,5.632,0a.776.776,0,0,0-.6.309L.234,6.29A1.163,1.163,0,0,0,.256,7.718a.741.741,0,0,0,1.183-.026L5.614,2.483,9.545,7.672A.782.782,0,0,0,10.163,8a.761.761,0,0,0,.565-.264,1.162,1.162,0,0,0,.053-1.425\" fill=\"#7da431\"><\/path><\/g><\/g><\/g><path id=\"Color_Overlay\" data-name=\"Color Overlay\" d=\"M1499.546,1946.671l-3.931-5.188-4.175,5.208a.741.741,0,0,1-1.184.026,1.161,1.161,0,0,1-.021-1.427l4.794-5.981a.743.743,0,0,1,1.22.02l4.533,5.982a1.112,1.112,0,0,1,.218.669V1946a1.107,1.107,0,0,1-.271.737.758.758,0,0,1-.564.265A.783.783,0,0,1,1499.546,1946.671Z\" fill=\"#fff\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\"> <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f9d74e2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f9d74e2\" data-element_type=\"section\" id=\"TIMECTOMiA\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6b330ac\" data-id=\"6b330ac\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1ef3f11 elementor-widget elementor-widget-heading\" data-id=\"1ef3f11\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">TIMECTOM\u00cdA<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d5b1f9 elementor-widget elementor-widget-spacer\" data-id=\"4d5b1f9\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9960572 elementor-widget elementor-widget-heading\" data-id=\"9960572\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Indicaciones:<sup>1,4,5,15<\/sup>\n<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-78e33c6 elementor-widget elementor-widget-text-editor\" data-id=\"78e33c6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022 Pacientes con MG generalizada no timomatosa, con AChRA positivos y edad entre 18 y 50 a\u00f1os. Se recomienda temprano en la enfermedad, dentro de los primeros 2 a\u00f1os, debido a que mejora los resultados cl\u00ednicos, reduce las internaciones y la necesidad de inmunosupresi\u00f3n a largo plazo. (Evidencia aportada por el estudio Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy; Ver Secci\u00f3n Bibliograf\u00eda).<sup>5<\/sup><br \/>\u2022 Pacientes con AChRA positivos y respuesta inadecuada o efectos secundarios intolerables con la inmunoterapia.<br \/>\u2022 Pacientes con evidencia de timoma, independientemente del tipo de miastenia.<br \/>\u2022 Pacientes con MG seronegativa no timomatosa, que no responden o presentan efectos adversos intolerables a los inmunosupresores.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3821755 elementor-widget elementor-widget-spacer\" data-id=\"3821755\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ceda281 elementor-widget elementor-widget-heading\" data-id=\"ceda281\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">No se recomienda para la MG:<sup>1,4<\/sup>\n<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-977a2c0 elementor-widget elementor-widget-text-editor\" data-id=\"977a2c0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022\u00a0 \u00a0 \u00a0 \u00a0 Con Ac anti MuSK positivos (es infrecuente la patolog\u00eda t\u00edmica asociada).<br \/>\u2022\u00a0 \u00a0 \u00a0 \u00a0 Ocular no timomatosa, sin generalizaci\u00f3n.<br \/>\u2022\u00a0 \u00a0 \u00a0 \u00a0 De comienzo despu\u00e9s de los 55 a\u00f1os, no timomatosa (involuci\u00f3n glandular por la edad).<\/p><p>Se prefiere la timectom\u00eda transesternal extendida para garantizar la remoci\u00f3n de la totalidad del tejido glandular.<sup>1,5<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-141ea2f elementor-align-right elementor-widget elementor-widget-button\" data-id=\"141ea2f\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#\" class=\"elementor-button-link elementor-button elementor-size-xs\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" width=\"11\" height=\"8\" viewBox=\"0 0 11 8\"><defs><clipPath id=\"clip-path\"><rect id=\"Rectangle_8\" data-name=\"Rectangle 8\" width=\"11\" height=\"8\" transform=\"translate(0 0)\" fill=\"none\"><\/rect><\/clipPath><\/defs><g id=\"Arrow_4_copy_5\" data-name=\"Arrow 4 copy 5\" transform=\"translate(-1490 -1939)\"><g id=\"Arrow_4_copy_5-2\" data-name=\"Arrow 4 copy 5\" transform=\"translate(1490 1939)\"><g id=\"Group_17\" data-name=\"Group 17\"><g id=\"Group_16\" data-name=\"Group 16\" clip-path=\"url(#clip-path)\"><path id=\"Path_16\" data-name=\"Path 16\" d=\"M10.782,6.311,6.249.328A.788.788,0,0,0,5.632,0a.776.776,0,0,0-.6.309L.234,6.29A1.163,1.163,0,0,0,.256,7.718a.741.741,0,0,0,1.183-.026L5.614,2.483,9.545,7.672A.782.782,0,0,0,10.163,8a.761.761,0,0,0,.565-.264,1.162,1.162,0,0,0,.053-1.425\" fill=\"#7da431\"><\/path><\/g><\/g><\/g><path id=\"Color_Overlay\" data-name=\"Color Overlay\" d=\"M1499.546,1946.671l-3.931-5.188-4.175,5.208a.741.741,0,0,1-1.184.026,1.161,1.161,0,0,1-.021-1.427l4.794-5.981a.743.743,0,0,1,1.22.02l4.533,5.982a1.112,1.112,0,0,1,.218.669V1946a1.107,1.107,0,0,1-.271.737.758.758,0,0,1-.564.265A.783.783,0,0,1,1499.546,1946.671Z\" fill=\"#fff\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\"> <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6c5b524 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6c5b524\" data-element_type=\"section\" id=\"INMUNOGLOBULINA\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1047f32\" data-id=\"1047f32\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9c82abc elementor-widget elementor-widget-heading\" data-id=\"9c82abc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">INMUNOGLOBULINA INTRAVENOSA \/ PLASMAF\u00c9RESIS <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f72880f elementor-widget elementor-widget-spacer\" data-id=\"f72880f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ec67c9 elementor-widget elementor-widget-text-editor\" data-id=\"0ec67c9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>\u2022 Ambas terapias tienen indicaci\u00f3n cuando se requiere la r\u00e1pida mejor\u00eda de los s\u00edntomas, como durante una crisis miast\u00e9nica, o durante el per\u00edodo perioperatorio.<sup>1,4<\/sup><br \/>\u2022 La plasmaf\u00e9resis (recambio plasm\u00e1tico), elimina r\u00e1pidamente los autoanticuerpos de la circulaci\u00f3n sangu\u00ednea.1<br \/>\u2022 En la MG con AC anti MuSK que presenta crisis o exacerbaci\u00f3n, se prefiere la plasmaf\u00e9resis sobre las inmunoglobulinas intravenosas (IgIV).<br \/>\u2022 El mecanismo de acci\u00f3n de las IgIV no est\u00e1 completamente aclarado.<sup>1<\/sup><br \/>\u2022 Como alternativa para ciertos casos, puede administrarse una formulaci\u00f3n de Ig por v\u00eda subcut\u00e1nea.1<br \/>\u2022 El beneficio cl\u00ednico de la plasmaf\u00e9resis y la IgIV dura entre 4 y 8 semanas.<sup>1<\/sup><br \/>\u2022 Para ambas terapias se requiere un acceso venoso y, en algunos casos, una v\u00eda central.<sup>1<\/sup><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ccc4f4e elementor-widget elementor-widget-spacer\" data-id=\"ccc4f4e\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e8e623 elementor-align-right elementor-widget elementor-widget-button\" data-id=\"3e8e623\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"#\" class=\"elementor-button-link elementor-button elementor-size-xs\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t<span class=\"elementor-button-icon elementor-align-icon-right\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" width=\"11\" height=\"8\" viewBox=\"0 0 11 8\"><defs><clipPath id=\"clip-path\"><rect id=\"Rectangle_8\" data-name=\"Rectangle 8\" width=\"11\" height=\"8\" transform=\"translate(0 0)\" fill=\"none\"><\/rect><\/clipPath><\/defs><g id=\"Arrow_4_copy_5\" data-name=\"Arrow 4 copy 5\" transform=\"translate(-1490 -1939)\"><g id=\"Arrow_4_copy_5-2\" data-name=\"Arrow 4 copy 5\" transform=\"translate(1490 1939)\"><g id=\"Group_17\" data-name=\"Group 17\"><g id=\"Group_16\" data-name=\"Group 16\" clip-path=\"url(#clip-path)\"><path id=\"Path_16\" data-name=\"Path 16\" d=\"M10.782,6.311,6.249.328A.788.788,0,0,0,5.632,0a.776.776,0,0,0-.6.309L.234,6.29A1.163,1.163,0,0,0,.256,7.718a.741.741,0,0,0,1.183-.026L5.614,2.483,9.545,7.672A.782.782,0,0,0,10.163,8a.761.761,0,0,0,.565-.264,1.162,1.162,0,0,0,.053-1.425\" fill=\"#7da431\"><\/path><\/g><\/g><\/g><path id=\"Color_Overlay\" data-name=\"Color Overlay\" d=\"M1499.546,1946.671l-3.931-5.188-4.175,5.208a.741.741,0,0,1-1.184.026,1.161,1.161,0,0,1-.021-1.427l4.794-5.981a.743.743,0,0,1,1.22.02l4.533,5.982a1.112,1.112,0,0,1,.218.669V1946a1.107,1.107,0,0,1-.271.737.758.758,0,0,1-.564.265A.783.783,0,0,1,1499.546,1946.671Z\" fill=\"#fff\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"elementor-button-text\"> <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43797fec elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43797fec\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7a96613c\" data-id=\"7a96613c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-73c7865 elementor-widget elementor-widget-spacer\" data-id=\"73c7865\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2e330d elementor-widget elementor-widget-text-editor\" data-id=\"d2e330d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><b>Referencias: 1<\/b>. . Pascuzzi R, Bodkin CL. Chapter 53. Disorders of the neuromuscular junction. En: Jos\u00e9 Biller. Practical Neurology Fifth edition. Philadelphia: Wolters Kluwer; 2017. p. 685-696. 2. Hoch W, McConville J, Helms S, et al. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nature Medicine 2001;7(3):365-8. <b>3.<\/b> Bubuiok AM, Kudebayeva A, Turuspekova S, et al. The epidemiology of myasthenia gravis. J Med Life 2021;14:7-16. <b>4. <\/b>Beloor Suresh A, Asuncion RMD. Myasthenia Gravis. [Actualizado en agosto de 2021]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. En: <span style=\"color: #5b82f0;\"><a style=\"color: #5b82f0;\" href=\"https:\/\/www.statpearls.com\/ArticleLibrary\/viewarticle\/25411\" target=\"blank_\">https:\/\/www.statpearls.com\/ArticleLibrary\/viewarticle\/25411<\/a> <\/span><b>5. <\/b>Wolfe GI, Kaminski HJ, Aban IB, et al. Randomized trial of thymectomy in myasthenia gravis. N Engl J Med. 2016;375(6):511-22.<b> 6<\/b>. Deymeer F. Myasthenia gravis: MuSK MG, late-onset MG and ocular MG. Acta Myologica. 2020; 39(4):345-52. <b>7.<\/b> Fichtner ML, Jiang R, Bourke A, et al. Autoimmune pathology in myasthenia gravis disease subtypes is governed by divergent mechanisms of immunopathology. Front Immunol. 2020;11:776.<b> 8. <\/b>Borges LS, Richman DP. Muscle-specific kinase myasthenia gravis. Front Immunol. 2020;11:707. <b>9. <\/b>Burden SJ, Yumoto N, Zhang W. The Role of MuSK in Synapse Formation and Neuromuscular Disease. Cold Spring Harb Perspect Biol. 2013;5:a009167. <b>10. <\/b>Koneczny I, Stevens J, De Rosa A, et al. IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients. J Autoimmun. 2017;77:104-15. <b>11. <\/b>Lascano A, Lalive PH. Immunosuppressive therapy of myasthenia gravis. Autoimmun Rev. 2021;20(1):102712. doi: 10.1016\/j.autrev.2020.102712. <b>12. <\/b>Rodolico C, Nicocia G, Damato V, et al. Benefit and danger from immunotherapy in myasthenia gravis. Neurol Sci. 2021;42:1367-1375. <b>13.<\/b> Alabbad S, AlGaeed M, Sikorski P, Kaminski HJ. Monoclonal antibody-based therapies for myasthenia gravis. BioDrugs. 2020;34:557-566. <b>14. <\/b>Xiao H, Wu K, Liang X, Li R, Lai K. Clinical efficacy and safety of eculizumab for treating myasthenia gravis. Front Immunol. 2021;12:715036. <b>15.<\/b> Narayanaswami P, Sanders DB, Wolfe G, et al. International Consensus Guidance for management of myasthenia gravis. 2020 Update. Neurology. 2021;96:114-122.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>TRATAMIENTO En la actualidad, el objetivo del tratamiento es que el paciente alcance la remisi\u00f3n completa o el estado de m\u00ednima manifestaci\u00f3n, es decir, que se encuentre asintom\u00e1tico y sin limitaciones funcionales causadas por la enfermedad. Estos beneficios deben acompa\u00f1arse de los m\u00ednimos efectos adversos que sea posible.11 Las estrategias terap\u00e9uticas son cuatro: TRATAMIENTO SINTOM\u00c1TICO [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false},"_links":{"self":[{"href":"https:\/\/centrodemiastenia.com\/medicos\/wp-json\/wp\/v2\/pages\/431"}],"collection":[{"href":"https:\/\/centrodemiastenia.com\/medicos\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/centrodemiastenia.com\/medicos\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/centrodemiastenia.com\/medicos\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/centrodemiastenia.com\/medicos\/wp-json\/wp\/v2\/comments?post=431"}],"version-history":[{"count":121,"href":"https:\/\/centrodemiastenia.com\/medicos\/wp-json\/wp\/v2\/pages\/431\/revisions"}],"predecessor-version":[{"id":1006,"href":"https:\/\/centrodemiastenia.com\/medicos\/wp-json\/wp\/v2\/pages\/431\/revisions\/1006"}],"wp:attachment":[{"href":"https:\/\/centrodemiastenia.com\/medicos\/wp-json\/wp\/v2\/media?parent=431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}